Theres the traditional Lazy Jacks and theres EZ Jax and others similar to EZ Jax that are retractable. When raising the main sail they are stored along the mast and boom and don't interfere with the sail.
That said, I have raised the Main numerous times with the EZ Jax deployed with no issues, as long as your dead into the wind. Maybe its because I don't have a full battened sail? I don't get all the issues folks mention regarding their concerns with Lazy/EZ Jax
Dutchman system is also a notable mainsail handling system but I don't much care for them. Add to that, changing out those monofilment lines every few years is no fun, its also pricey for what you get IMO. A Bristol 35.5 I used to sail on had them.