Perhaps it's my ground-pounder background, but I prefer course up. Like Kelly mentioned, that's standard for navigating with topo maps and that's how I did it for 20+ years in the Army. Aviators also tend to use course up -- especially those who are moving fast and are at risk of hitting massive, immovable objects (like mountains.)
I do navigate with the plotter "north up" on occasion, and don't find it difficult but always seem to migrate back to "course up."
I guess it's kind of like the debate over Hellman's or Miracle Whip -- no right answer, just personal preference. (And yes, I'm a Miracle Whip guy