I have owned many 2 stroke outboards & motorcycles over the last 66 years. Properly taken care of they are hard to kill. However, they don't like being run flat out very long in a lean condition, kind of melts holes in the top of pistons. But they sure do sound good right up until the time they melt. Now days, with fixed high speed jets that shouldn't be that much of a problem, unless one "tinkers" with them.
I have "run them dry" for many years with no adverse effects. About 20 years ago I started draining the carb as running them dry leaves a small amount of fuel in the bowl.
Never had much problem with fuel left in the carb until I started using 4 strokes, which I now drain religiously if they are not to be used for more than a week or so.
As mentioned, reading the owners manual helps, seems like they are always right, when printed correctly.