A quick plot shows 325-350 NM from Oriental. As you may know, there are some large bodies of water to traverse on that route. This time of year the fronts dropping down from the N and NE can make the route pretty sporty.
Are you planning to have a delivery captain move the boat or will you do it yourself? From a few of your other posts I have the impression this may be your first boat and I am not clear how much experience you have. If you plan to take the boat, will you have an experienced crew and if so how many.
Camaraderie's estimate of 50-60 miles per day might be a bit much if you are new to the boat and your crew is not sufficiently experienced. sailingdog makes good points about your planned cruising speed. While the tides in the Pamlico and Albemarle Sounds are mostly wind driven a large portion of your planned trip is up the Chesapeake Bay. A quick look at Reed's for he East Coast suggests tides in the 1-3 knot range.
A more conservative 30-40 N miles per day might be advisable as a planning estimate. Then you should build in a number of weather days when you won't be able to move.
Anyway, a few thoughts from another Oriental boatowner.
Good Luck on your trip. Be safe and don't push a bad position just to get there. Leave yourself plenty of time and the trip should be a real nice adventure as spring comes on.