I've been up 3 times and once up the 30,000 island inland route. It is fantastic. The Ports Guide is great.
The Pool is getting very weedy. It's no problem for anchoring as there is never any wind but it makes the water less than perfect. It's still worth a visit. The Okechobee lodge is now private so take everything you need with you as you'll be a long days sail from any towns.
Make sure your depth finder works!