The Detroit River at downdown gets very choppy at times. Wind against current plus powerboat traffic can make it miserable. Try to get there early. Usually the Canadian side is less choppy but not by much. The Trenton channel will be the nicest part of the trip.
If you are going past Metro Beach/Black Creek, watch for the very weedy area just off Metro Beach. Stay well east of that spot, the weeds plus the shallow water will cause you grief. It's marked on the chart but a lot of boats cut across that area.
If you need to make a third day, Keans marina near the Roostertail makes a good stop. The Nautical Mile marinas in St Cl Sh have transient slips but I don't know what channel they monitor. You might have to cruise up to the gas dock to ask, they have plenty of empty slips these days!