We recently went through this decision, and ended up buying a center cockpit. We were drawn towards center cockpit from the mind of having a cockpit enclosure, as our intentions are year round sailing in the puget sound. Many people do enclosures with aft cockpits as well, though aesthetically and functionally they don't work for me (at least in beamy modern designs). Once my fiance saw the aft cabin you get, there was pretty much no going back.
The other downside, my good friend with a beneteau 423 keeps reminding me of, is the reduced size of the salon area. This of course depends on perspective, as many will point out the giant salon could become a hazard if you are offshore.
Depends a lot on the size of boats you are considering.