You said docking will be harder, I believe you. I don't know in what ways it will be harder, but I think you are right that it probably will be harder.
With a twenty something boat your probably talking about 2000 to 3500 lbs moving into the slip at say 1 knot You jump onto the dock with dock lines in hand maybe grab a stanchion to slow the boat and tie it up.
Now repeat that with a 10,000 to 12,500 lb boat. Stop that at 1 knot by man handling it. Lets add in an adverse wind or current and it's even more fun. Also a larger boat will have a higher free board to step off of.
This is all mitigated by developing docking skills for the larger boat. It's very doable just don't think you man handle the boat all the time like you can with a 22.
2007 Hunter 49