Yes, extended cruising can be done in a catboat. I'd highly recommend you read Catboat Summers, by John Conway, which is about just that. He sailed various catboats out of the Buzzards Bay area. I don't see why you couldn't cross the Gulf Stream to the islands, provided you timed it properly with a good weather window.
To cruise with two people aboard a 22' catboat would require that the two be very friendly.
I'd also recommend you read the post in my signature to help you get the most out of your time on sailnet.
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You know what the first rule of sailing is? ...Love. You can learn all the math in the 'verse, but you take
a boat to the sea you don't love, she'll shake you off just as sure as the turning of the worlds. Love keeps
her going when she oughta fall down, tells you she's hurting 'fore she keens. Makes her a home.
—Cpt. Mal Reynolds, Serenity (edited)
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Still—DON'T READ THAT POST AGAIN.