On a Bristol 45.5 in NYC area
My wife and I are living on a center-cockpit Bristol 45.5. It is very comfortable and has pretty much all of the comforts of home. I think I would have preferred something around 40 feet, but the Admiral suggested that we move aboard as long as we picked a boat that she would be comfortable on for longterm.
Our plan is to stay here until August 2010 and then go south. We would likely go to Europe in the spring of 2011 and then cruise in the summer and live aboard in London for at least one winter.
The only problem, and it is something that one can live with - is doing chores on the boat while living on it. I am updating many of the systems (new refrigeration likely this weekend) and doing the varnish a bit at a time.