If the Practical Sailor is to be trusted (and I do not know any other source of info with the same degree of thoroughness) the Interlux ablative multi season paints are holding pretty good.
3 years ago I've sanded my bottom to gelcoat, used Interprotect barrier coat and Interlux Micron. 2 seasons later there where some barnacles and no other problems. This spring I've lightly sanded and painted again with Interlux ablative.
I expect it to be good only with minor touch ups for a couple of seasons again.
It makes sense for me to stick with the complete line of products from the same manufacturer for the whole job. And my opinion is the interlux products and customer support are not bad.
I would advise you to read their info on
and following the directions should give you a great results.
I had little or no experience working on boats and if the current condition of my boat is of any indications anybody could do it. I would say, sanding off the old payers of paint was the hardest part.