Depends on what you are looking for.
Hubby and I are transitioning from lake sailors to coastal cruisers. We planned to spend a good part of the winter (might not happen - family issues) on the St. Johns. Protected river sailing with ICW access, bridges, ships traffic, etc. to expand our experience. Not to mention plenty of area to explore.
Jax has a large airport and mass transit, available rental cars if needed, and other city amenities.
And I have family there. For us it is a good destination.