Motoring for hours is easier on the engine than short start stops. Start with fresh fuel if you do not know how old it is. and Check everything of course.
It could have problems and you do not want to find that out half way home but it could happen so keep that in mind.
Locks shouldn't be a problem other than getting lines secured and being able to pull them in or let them out as required.
Time? Start early morning, try to catch the tides should be doable in a day but days are kinda short this time of year so I'm not sure.