First of all, Congratulations!
Keep in mind that once you get to the area of Santa Barbara isalnd, you are away from coastal influences and are likely to find higher seas and winds...
MDR is quite a ways out of the way. I'd either go with your Isthmus plans, or maybe Avalon.
Other option is to leave at dawn from Alamitos bay and plan to arrive home at night. You know the area, right?
1987 CS 36 Merlin "Kyrie"
"They drove a dump truck full of money up to my house. I'm not made of stone!" -Krusty the Clown