[CrazyRu]

I did travel both panhandle and keys. If you looking for beaches, clean water and protected anchorages, panhandle wins.
There are a lot more manmade attractions in Keys, it is a lot more diverse, both naturally and culturally and it is beautiful, I love Keys, however if your objective is to spend quiet week of sailing and viewing nature and having least interaction with two legged species, I'd choose panhandle, or 10000 islands area of Florida.