No, but I am considering the Keys as an alternative to getting my butt kicked leaving the NE for Bermuda & the Caribbean next fall. Spent years in the Keys running diving & fishing charters (so I know I'll eat well!), but this is the first time I'll be cruising a deep draft vessel there.
If I do go, I'll probably spend most of my time way out west, the Dry Tortugas, etc, depending on the park rules when I get there.
Of course, Martinique (French wine, cheese & bread) also beckons....