No, no, no - you're doin' it all wrong.
Very nice anchorage can be had by bypassing Cockrell Creek and don't go up there - because, as has been observed, IT STINKS!
Instead, head straight up the Great Wicomoco and go up and around Sandy Point. It's clearly shown on the NOAA charts. Once you pass Sandy Point on your port side, turn to port and go well into that curved little cove, and you'll find a lovely, quiet anchorage with excellent holding.
I took this photo there 11 months ago:
The only mistake I made was not going far enough into the little cove area - we were just barely inside the protective arm of Sandy Point, so we still caught a little breeze and very light chop from passing boats. If we had gone a couple hundred yards farther in, closer to shore, where a couple other boats were anchored, we could see the water was much flatter there.
It was a beautiful evening and a great place to anchor. I'd go there again.
And you're far enough away from the fish processing plants at Reedville that you don't smell them.