I enjoy sailing single-handed and have generally single-handed more than not, but less since so since I got married. Probably the only change that I do when single-handed is that I used twings on the spin sheet on shorter passages, rather than putting the sheet in and out the snatch block with each jibe.
Like everyone said, its all about planning ahead. I typically have two reefs roved that I can pull in from the cockpit when single-hand (although I have never needed more than a first). I have specially cut jibs which are intended have very wide wind ranges. I use an inflatable harness and jack lines. I tend to use the autopilot more frequently and the spinnaker a little less. I use the winches closest to the wheel more, and the forward winches less. I center the traveller when short tacking into a tight channel rather than playing. I rig dock lines and bring them outboard to amidships before coming in. But otherwise single-handing not all that much different.
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Curmudgeon at Large- and rhinestone in the rough, sailing my Farr 11.6 on the Chesapeake Bay