We had a MOB a few years ago. Fired up the atomic four as soon as we threw a floatation device and eased off the sheets. We were in moderately heavy seas with winds somewhere around 18 knots. We picked up our MOB within a few minutes and we continued on our way.
Our engine room received ventilation while were are moving, so no worries about fumes building up in the bilge.
Hope you can keep your crew on board.