48 North had a good article about a year ago that was titled something like the "The Weenie Route to Southern California" that did a good job of retelling a couple's trip south by hopping from bay to bay all the way down. They waited for weather windows, and ended up with a series of relatively short hops.
I also believe there's a Charlie's Charts for the Pacific Coast that can help with such a route.
Finally, there's a local sailor who is currently enroute down, using the hop method. His website is http://www.sailestrella.com/
, and so far he's gone from Portland to Newport, Oregon, and may have already moved on to either Coos Bay or Crescent City.
Others, of course, take the offshore route.