Stay on the starboard side of the canal, the north side, going Delaware to Chesapeake, on the south side Chesapeake to Delaware. The commercial vessel is constricted by draft, smaller pleasure vessels must yield.
After the commercial vessel passes jump its wake (may be 8ft trough to crest) and ride the calmer water between starboard and port wakes, unless another vessel is following, then stay to the side but keep an eye on the depth sounder.
No supertankers in the canal, large barges and a few smaller freighters, the control depth is 35ft.
I have transited with at times up to six commercial vessels passing and at other times with none.