If going for speed then definately ocean route the best.
Just make sure you have good wx forcasting tools and pick a good window.
If you are doing this short handed, perhaps break it up with a stop in Cape Cod?
How well do you know the boat? Is she in very good repair, that can impact your routing decision as well.
The other factor is your crew, do you have experianced off shore crew, or are they all newbies?