I have had an all-chain anchor rode in the past that gave excellent service.
The drawbacks to chain are associated with its weight. It will put a lot of it in the forward end of the boat and probably above the CG. It is also mighty heavy to recover and you will most likely require a windlass.
Lately, I have switched to a generous length of chain (perhaps equal to waterline length) and nylon for the balance. That puts the chain in contact with the bottom where it will resist abrasion, and the nylon stretches under load.
One last point. Chain eliminates the problem of chafe, while nylon requires watchfulness and careful application of chafing gear.