Crew in order to cruise. I believe I have the near-perfect boat for our plans already, but my ideas run counter to those in the majority of Margeritaville. Budget on buying two boats: one boat to buy, and a near-equivalent amount to equip her for world cruising. That's one reason why I bought a custom boat...they are never actually finished, and some stuff is missing (and can therefore be bought new), and the original stuff is old enough that I don't mind chucking it.
I would recommend a multi-year approach that includes spending several months as a liveaboard in your home port. That will allow you to get rid of all the junk you won't need, and will identify what's important and what is still required in the way of tools, spares, systems and safety.