I'm going to approach this from a different perspective. I'm currently not a live-a-board, but if my health holds up I intend to become one in October of 2012. However, if some doctor tells me that I have a catastrophic disease, then I'll be a live-a-board a week later.
My longest time spent living aboard was during a 10-day cruise I took from Havre de Grace, MD to Virginia Beach, VA. It was a neat trip, but I was essentially living aboard a Catalina 27, which after a week, seemed a bit cramped for cabin space.
My new boat, a 33 Morgan Out Island, is far more spacious, yet it's still small enough that I can readily handle it by myself. I intend to set sail in early October of next year and take the boat to Marathon Key, FL, then to Key West, the Dry Tortugas, maybe across to the Bahamas or down to Cozumel, Mexico before heading back to Maryland 7 months later. My wife thinks I totally nuts. "What the Hell is a 70-year-old man thinking?" She frequently asks. Well, I'm thinking about palm trees, snow-white sand, turquoise waters and balmy temperatures. What I no longer want to do is rake leaves, shovel snow, slide around on ice-covered roadways, and work my a$$ into an early grave. At age 70 I still work 5 to 7 days a week as an entertainer (musician/singer), and I soon hope to make some changes along those lines. Playing and singing at Tiki Bars in the Florida Keys during the dead of winter makes a lot more sense to me than performing at an Italian Restaurant in the middle of a Baltimore blizzard.
Now, I'm not yet in the throes of divorce, and after nearly 50 years with the same woman the chances of that are probably pretty slim, though I'm sure it has crossed both our minds during the past half-century. I'm fairly confident that my loving spouse will NOT be going with me on that trip, but she may fly down for an occasional visit now and then. Because of this, I'll be somewhat in the same situation as the OP, living a fairly lonely life aboard, watching TV, reading, doing a little fishing and sailing when the weather cooperates, and of course, playing music and singing to the ladies at the Tiki Bars. I'm not sure, but I'm guessing it will be a bit of a lonely lifestyle.
Now, if "absence makes the heart grow fonder," as the old saying goes, I suspect the old gal will get a house sitter, hop on a plane, and head south sometime after Christmas to visit an old man living aboard his boat. With luck, she'll spend a couple months, then head home to await my arrival about the end of May. At least I'm hoping that's how things will turn out.
Good luck on your venture, and I sincerely hope everything works out well for you in the not too distant future.