I have used and sailed many, many boats with mast mount domes. If you let the sail tack itself through the triangle, then pull the sheets, you'll rarely if ever have an issue. If you just start yanking on the sheets before the sail has naturally brought her self across you WILL tangle a dome..
In the last 20 years or so I have only caught the head sail once and that was on a mast mounted spin pole.. I would not mount it on a spreader. You may also get a larger
radar shadow to one side or the other because the mast is deeper than wide and the radome would be looking through the widest part of the mast section.
P.S. In the normally light Maine summer winds I usually run a #1 (150 genny) and still never had an issue with catching my sail...