Our boat is not suited to an enclosure, and I'm not quite ready (yet) anyway!
But.... many of our cruising buddies have recently added enclosures, in our area they tend to get used quite a lot. These are almost universally 'roll up' panels - I think that makes sense as it avoids having to find a good spot to store them below on a cruise. Most also have removeable 'zip outs' in the transition between dodger and bimini (which you probably already have)
We've seen our friends motor/motor sail with the side curtains in place, but most roll them up while sailing. We did some cruising in colder climes this summer together, the enclosures got a lot of use, esp in the mornings and in the evenings for entertaining. The cold water really cooled the cabin sole and space below, so the cockpit was more comfortable than below when enclosed.
Based on our observations, I'd pay close attention to maintaining access to cleats, rail mounted BBQs, outboards, etc, don't obscure the stern light, think about zippers vs snaps, and esp how the bottoms of the side curtains are going to attach to the deck/coamings. Have seen some coaming snap pins become literal PITAs
when the curtains are rolled up...
One good idea we saw was having the fwd side panel open from the front, fold back inside and snap into the inside of the enclosure.. like a door latched open. Saved rolling up that panel and made it easier to let people in and out.