Tony...we stayed at the Cape Coral Municipal Marina which provided easy access to Ft. Myers and was friendly and relatively inexpensive. You can also
anchor out inn the Caloosahatchie River but I wouldn''t call it an all weather anchorage. I''ve also seen people
anchor in the lee of the Sanibel Island Bridge in reasonable weather and of course there is a large fleet anchored in Ft. Myers Beach just past the bridge...but that is a ibt of a hike to SW Ft. Myers.
Hope this helps! GB