The most challenging part of this trip is narrow passage known as the stone bridge in Tiverton, where you could have trouble if you try to run against the tide which is very strong.
Also be aware that the Coast Guard and DEM established some restrictions to navigation around the Rt. 24 bridge construction area. You can find more details here: Retrieve Pages
If you are going this weekend, the Narragansett bay weather forecast indicates a few nice days are coming. Sat West wind 5-10 knots & Sun NW 5-10 knots. It looks like high tide will be ~6:30 am & 6:30 pm. So if you leave mid-day, you should have an incoming tide helping you along.
Check the weather before you leave and make sure you bring all of your safety gear, (life jackets, anchor, signals, etc.) and foul weather gear to keep you dry in case it it windier than the forecast. Also bring a few bottles of water to drink, sunscreen, and don't forget a camera to document your voyage. We'll be looking for your photos.
One of my embarrassing experiences with a small outboard on a sailboat was running out of gas while trying to make it up a tidal river against the tide, because the internal tank was so small. Even if you think you won't be motoring much, it might be a good idea to bring along a spare gas jug, unless your outboard has an external tank of at least a couple of gallons.
This is a pretty protected passage, so you should do fine.