Two chemicals are used to lower the freezing point of water in "permanent" antifreeze - ethylene glycol and propylene glycol. Ethylene glycol is used in the green antifreezes. It is both sweet and quite toxic. Ethylene glycol has a serious problem when used as an antifreeze, which is that it gradually forms a gum that coats or plugs the cooling passages, so ethylene glycol antifreeze needs to be flushed and replaced every few years. Ethylene glycol antifreeze is obsolete. For example, Yanmar does not approve using it, and using it could void a warrantee. You may have noticed that the antifreeze for modern cars is pink. Pink is an international standard color for substances that are not very toxic. Pink antifreeze is made with propylene glycol. You may have noticed newer pink antifreezes advertised as good for 150,000 miles. These are modern propylene glycol antifreezes. The antifreeze used to winterize RVs and boats is also pink, because it is nontoxic; it is also made with propylene glycol. Propylene glycol is a permitted food additive; for example, it is added to shredded coconut to keep it moist. As other posters have indicated, winterizing antifreeze should not be used in closed loop cooling systems, because it lacks the corrosion inhibitors, water pump lubricants, and other additives that engines need. One sure way to select your closed-loop antifreeze is to check what your engine manufacturer recommends. When I did this for Yanmar, I encountered four tested and approved brands, all based on propylene glycol.