It all depends on your boat and the conditions that day. I would set a course five or ten degrees to windward of the rhumb line to your destination. Plan to adjust your course to leeward as you progress toward you destination, trying to keep the boat pointing a bit to windward of your destination. As you get closer to your destination you'll be able to sail a more direct course. Remember, it's usually easier (and faster) to error to windward and fall off a little, rather error to leeward and have to point up (or even tack), to make it to you destination.